Pharmalogical action of raloxifene

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Raloxifene - pharmacological action. The selective modulator estrogene receptors. Operates as agonist on the fabrics of the organism which has been not connected with a reproduction, and as the antagonist - on reproductive fabrics. The action mechanism is connected with high afinne linkage with estrogens receptors and regulation of an expression of genes. Reduces process resorbtion a bone fabric and normalises balance of calcium of an organism, first of all at the expense of reduction of losses of calcium with urine. Does not cause proliferation endometry, increases in the sizes of a uterus, blood or bleedings in the postclimacteric period. It is not described cases of occurrence of a cancer эндометрия de novo. Does not cause hyperplasia a fabric of mammary glands. Reduces swelling and morbidity of mammary glands. Reduces levels of the general cholesterol and LPNP. Level LPNP and hlycerids  authentically does not change, though concentration of subfraction LPVP-S2 increase. Reduces the maintenance fibrynogene blood plasmas.

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