Economic evaluation of chemoprevention of breast cancer with tamoxifen and raloxifene among high-risk women in Japan. The Sensitivity analysis
To be dealt with uncertainty of probability, utility weight, and costs were used in our economic model, the unilateral analysis of sensitivity is executed. The transitive probability from a healthy condition to conditions of illness shown on the Table 1 is changed in 1.5 times of intervals of 95 % of trust (CI) informed of clinical tests. 95 % CI are often used for similar realisation by the sensitivity analysis, but we have established more widely diapason for applicability clinical skilled given to the Japanese women. Other probability shown in Table 2 is changed 50 %. The Utility weight is changed 20 %, and we think it could cover distinction between weight of the utility of the Japanese women and those another developed countries. Costs shown in Table 3 are changed 50 %. The considered rate also is replaced with 0 with 6 %.
Recognising long-term results for cheap raloxifene in IBIS-Я test (Cuzick et al, 2007) and Royal test Marsden (Powles et al, 2007), reductional effect of risk tamoxifen are prolonged from 5 till 10 and 15 years without any increase in risk of adverse events after preventive maintenance end
Tags: Evista, Raloxifene
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