Economic evaluation of chemoprevention of breast cancer with tamoxifen and raloxifene among high-risk women in Japan. Economic efficiency

Costs
In comparison between preventive maintenance with tamoxifen against any preventive maintenance (the Table 4), standing expenses are estimated in higher classifications of risk, among women with history LCIS or AH, beginning at younger age. The greatest economy? 367901 (? 1840), it is estimated among women with history AH to begin at the age of 35.

Between preventive maintenance with raloxifene against any preventive maintenance, prophylaxes are found out more expensive. Economy of cost? 10387 (? 52), are estimated among women with history AH to begin at the age of 50.

Considering a therapeutic key of the policy (the Table 5), use raloxifene consistently is more expensive than tamoxifen as it is assumed by distinction in the price of agents.
Economic efficiency

There is an offered criterion for economic efficiency in Japan (Ohkusa, 2003) to be? 6000000 (? 30000) for one QALY a gain, and as Tables of 4 and 5 decisions of the message with this criterion.
In comparison between preventive maintenance with tamoxifen against any the preventive maintenance, favorable results that cost less and a gain more ‘ or economic, are received in higher classifications of risk beginning at younger age. Those: women with history AH irrespective of start grow old, women with history LCIS beginning at the age of 35 both 50, and women with 5th year predicted a cancer of a breast of risk of 5.01 % beginning at the age of 35 and 50.

Similar results are found out between preventive maintenance with raloxifene against any preventive maintenance. Favorable results: women with history AH irrespective of start grow old, women with history LCIS beginning at the age of 50, and women with 5th year predicted a cancer of a breast of risk of 5.01 % beginning at the age of 50.

As shown in Table 5, ICERs for a therapeutic key of the policy of the preventive agent from tamoxifen that cheap  raloxifene changes from? 1839670 for QALY (? 9198 for QALY) on? 6771100 for QALY (? 33856 for QALY). Больший ICER while still close to the offered criterion? 6000000 for QALY (? 30000 for QALY).

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